Evidence supporting the use of: Lactobacillus (various species)
For the health condition: Bladder Infection

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus species have been investigated for their potential role in preventing and managing bladder infections (urinary tract infections, UTIs), particularly recurrent UTIs in women. The scientific rationale is based on the observation that a healthy vaginal and periurethral microbiome, dominated by Lactobacillus, can inhibit the colonization and growth of uropathogenic bacteria such as Escherichia coli. Mechanisms proposed include the production of lactic acid (lowering pH), hydrogen peroxide, and bacteriocins that inhibit pathogen growth, as well as competition for adhesion sites on mucosal surfaces.

Several clinical studies and meta-analyses have explored the use of oral or intravaginal Lactobacillus probiotics for UTI prevention. Some small randomized controlled trials suggest a modest reduction in UTI recurrence, especially with certain strains (e.g., L. crispatus). However, results are inconsistent, with other studies not showing significant benefit compared to placebo. Systematic reviews generally conclude that while there is biological plausibility, the overall evidence is limited by small sample sizes, heterogeneity in probiotic strains and regimens, and methodological weaknesses.

Thus, the use of Lactobacillus for bladder infection is supported by a scientific rationale and some early clinical evidence, but robust, large-scale clinical validation is lacking. It is not considered a replacement for standard antibiotic therapy but may be considered as an adjunct or preventive measure in select populations, especially those seeking non-antibiotic options for recurrent UTI prevention.

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