Evidence supporting the use of: Enzyme (unspecified)
For the health condition: Bleeding (external)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Enzymes, particularly proteolytic enzymes such as papain (from papaya), bromelain (from pineapple), and certain bacterial or fungal-derived enzymes, have been used traditionally in wound care, including for external bleeding. In folk and traditional medicine, topical application of enzyme preparations was believed to help clean wounds, remove dead tissue, and sometimes promote clotting and healing, thereby indirectly addressing bleeding. For example, papain has a long history of topical use in tropical regions for wound debridement. However, the direct hemostatic (blood-clotting) effect of these enzymes is limited or controversial; some proteolytic enzymes may even increase bleeding risk if not used carefully. There is moderate clinical evidence for the use of certain enzyme-containing ointments in wound debridement and healing, but little high-quality evidence supports their direct use to stop external bleeding. Modern medicine typically uses other agents (like pressure, sutures, or chemical hemostatic agents) for bleeding control. In summary, while there is a traditional basis for enzyme use in wound care, their direct application to treat external bleeding is not strongly supported by scientific evidence, with their primary traditional role being wound cleaning rather than hemostasis.

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