Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Fibrinase is an enzymatic preparation commonly used as a topical agent to support the management of external bleeding. Fibrinase contains proteolytic enzymes, such as fibrinolysin and deoxyribonuclease, which are derived from bovine plasma and certain bacterial sources. The scientific rationale for its use lies in its ability to aid in the enzymatic debridement of wounds, removal of necrotic tissue, and promotion of wound healing, which can indirectly help control bleeding by creating a cleaner wound environment conducive to hemostasis and tissue regeneration.

Several clinical studies and case reports support the efficacy of Fibrinase and similar enzyme-based preparations in wound management, particularly for chronic, non-healing wounds and ulcers. The enzymatic action does not directly stop bleeding (hemostasis), but by facilitating the removal of dead tissue and promoting healthy tissue growth, it supports the natural cessation of bleeding and accelerates healing. This is especially beneficial in cases where bleeding is persistent due to underlying infection or necrotic debris. The evidence base includes randomized controlled trials and observational studies, as well as recommendations from wound care guidelines. However, it should not be used in cases of acute, severe, or arterial bleeding, as it does not act as a direct hemostatic agent.

In summary, the use of Fibrinase for supporting treatment of external bleeding is scientifically validated, largely in the context of chronic or difficult-to-heal wounds where bleeding is secondary to tissue necrosis and infection. The evidence supports a rating of 4 out of 5 for this indication.

More about fibrinase
More about Bleeding (external)

Other ingredients used for Bleeding (external)

Abrus
Abuta
Acacia
Achyranthes
Agrimonia pilosa
Agrimony
Ajuga
Alchemilla
Alchornea
Alkanna
Aloe vera
Alstonia macrophylla
American Liverleaf
Amor seco
Angelica
animal Tissue
Aquilegia formosa
Ardisia
arnica
ash
Ashoka
asiaticoside
Asteraceae
avens
bai ji
Baliospermum
balsam
bamboo
Baphicacanthus cusia
Barleria
basil
bayberry
bee products
bee propolis
bentonite
benzoin
bermuda grass
betel
bethroot
betony
Bidens pilosa
bioflavonoids
bishop\'s weed
bistort
black cumin
black nightshade
black root
black-eyed Susan
blackberry
blackthorn
Bletilla
bloodroot
Boerhavia diffusa
Bombax
borneol
boxthorne
Brazilian peppertree
bur-reed
Butea monosperma
Caesalpinia crista
Calendula
camphor oil
capillary artemisia
capsicum
Carthamus
Casearia esculenta
catechu
catkin
cayenne pepper
cedar
Cedrus libani
celandine
Centipeda
chamomile
chickweed
Chinese raisintree
chlorophyllin
cinquefoil
Clerodendrum indicum
cocklebur
commiphora
common madia
Coptis chinensis
cornflower
cowherb
cranesbill
curcumen
curcumin
Cyathula
cypress
devil\'s club
Dianthus
dragon\'s blood
Eclipta
elephant\'s head
Erigeron
Erodium cicutarium
essential oil blend
Eupatorium
Euphorbia
Eupolyphaga sinensis
European Elder
fern
fibrinase
Ficus religiosa
fleabane
Fomes fomentarius
fungus
Galium
gallotannin
Gambir
Genipa americana
geranium
ghatti
Glechoma hederacea
Gnaphalium
Golden Willow
Guazuma ulmifolia
heal-all
Helicteres isora
hemp
henna
Herb Robert
herbal blend (proprietary)
Homalomena
honey
Horsemint
horsetail
hound\'s tongue
Huang hua
Indian fagonia
Indian gum arabic tree
Indian kinotree
Jessica\'s sticktight
juglans cinerea
Kachnar
Kokilaksha
labrador tea
Leptospermum scoparium
Lesser speargrass
Levant cotton
Lewis's monkey flower
lichen
Litsea
little ironweed
lodhtree
Lysimachia
Macaranga indica
Malva sylvestris
marigold
Matapalo Tree
Matico
Microcos
Moss
Mountain mahogany
Mugwort
Myrobalan
Myrrh
Nasturtium
Oak
Osha
Oxystelma
pagoda tree
papaya
parthenium
paw paw
peony
Peucedanum
Phyllanthus
Plantago
plantain
polymorpha
Portulaca
Potentilla
Propolis
protein
Prunus
purple loosestrife
queen of the meadow
raspberry
red spiderling
resin
Rhus glabra
Rosa californica
Rubia yunnanensis
Rubus
rue
sage
Sangre de Grado
Sanguisorba
Sanicle
scrophularia root
sea salt
Self-Heal
Sensitive Plant
Sesbania
sheep's sorrel
shen-chu
shepherd's purse
Sichuan Lovage
Sickle-leaf hare's ear
Silverweed
Smartweed
Smooth Alder
Solanaceae
Southern Tsangshu
Speedwell
Spilanthes
squawvine
Stellaria dichotoma
Stereospermum
Stone Root
Sumac
Tagetes
Tannins
Terminalia
Thaumatococcus daniellii
Trichosanthes
Tridax
Triterpenes
Vervain
Viola
Violet
vitamin C
vitamin K
White Heather
White oak
Willow
Wintergreen
Witch Hazel
Wood betony
Yarrow
Yerba buena
Yerba Mansa
zanthoxylum
Zingiberene

Other health conditions supported by fibrinase

Abrasions
Bleeding (external)
Bruises (healing)
Cuts
Injuries
Sprains
Wounds and Sores

Products containing fibrinase

We currently have no products on Vitabase that contain this ingredient.