Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Fibrinase is an enzymatic preparation commonly used as a topical agent to support the management of external bleeding. Fibrinase contains proteolytic enzymes, such as fibrinolysin and deoxyribonuclease, which are derived from bovine plasma and certain bacterial sources. The scientific rationale for its use lies in its ability to aid in the enzymatic debridement of wounds, removal of necrotic tissue, and promotion of wound healing, which can indirectly help control bleeding by creating a cleaner wound environment conducive to hemostasis and tissue regeneration.

Several clinical studies and case reports support the efficacy of Fibrinase and similar enzyme-based preparations in wound management, particularly for chronic, non-healing wounds and ulcers. The enzymatic action does not directly stop bleeding (hemostasis), but by facilitating the removal of dead tissue and promoting healthy tissue growth, it supports the natural cessation of bleeding and accelerates healing. This is especially beneficial in cases where bleeding is persistent due to underlying infection or necrotic debris. The evidence base includes randomized controlled trials and observational studies, as well as recommendations from wound care guidelines. However, it should not be used in cases of acute, severe, or arterial bleeding, as it does not act as a direct hemostatic agent.

In summary, the use of Fibrinase for supporting treatment of external bleeding is scientifically validated, largely in the context of chronic or difficult-to-heal wounds where bleeding is secondary to tissue necrosis and infection. The evidence supports a rating of 4 out of 5 for this indication.

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