Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Growth factors are biologically active proteins that regulate cell growth, proliferation, and differentiation. Their use in the context of treating or supporting external bleeding is primarily supported by scientific evidence, particularly in the field of wound healing and tissue repair. Platelet-derived growth factors (PDGFs), epidermal growth factor (EGF), and fibroblast growth factor (FGF) have been shown in multiple studies to accelerate wound healing by stimulating angiogenesis, granulation tissue formation, and re-epithelialization. These effects indirectly help control bleeding by promoting faster tissue regeneration and closure of wounds. However, growth factors are not used as primary hemostatic agents (which directly stop bleeding); rather, they support the healing process after initial hemostasis is achieved through conventional means such as pressure, suturing, or hemostatic dressings.

Clinical evidence includes the use of recombinant human platelet-derived growth factor (becaplermin) for diabetic ulcers and other chronic wounds, where improved healing rates have been documented. Additionally, topical application of growth factors in the form of gels, sprays, or incorporated into wound dressings is an emerging area, particularly in surgical and burn care. Meta-analyses and randomized controlled trials provide moderate evidence (hence a rating of 3) for their efficacy in enhancing healing, but direct evidence for the use of growth factors solely for bleeding control is limited. The main scientific rationale is their ability to promote rapid tissue repair, which can indirectly reduce the duration and risk of ongoing external bleeding.

More about Growth factors
More about Bleeding (external)

Other ingredients used for Bleeding (external)

Other health conditions supported by Growth factors

Products containing Growth factors