Alkanna, particularly Alkanna tinctoria (commonly known as alkanet), has a long-standing history of traditional use in herbal medicine, especially in Mediterranean and Middle Eastern regions. The root of Alkanna contains red pigments (naphthoquinones such as alkannin) and has been used as a topical remedy for minor wounds, burns, and skin irritations, including blisters. Traditional texts and folk medicine sources describe its application in ointments or salves to soothe the skin, promote healing, and provide a protective barrier. Some of these uses are based on the perceived anti-inflammatory and antimicrobial properties attributed to alkannin and related compounds. However, while there is some evidence from laboratory studies suggesting that Alkanna extracts may have antimicrobial and wound-healing activities, direct clinical studies on its efficacy specifically for blister treatment are lacking. The historical use is well documented, but scientific validation for its effectiveness on blisters is minimal. Therefore, its use for blisters is primarily justified by tradition, with a low rating for supporting evidence due to the absence of robust clinical trials.