American Liverleaf (Hepatica americana), also known as liverwort, has been used traditionally in North American herbal medicine. Its historical uses largely center around liver and respiratory complaints, with some Native American groups and 19th-century herbalists applying it topically for minor skin irritations, including blisters. The rationale behind such use was usually based on the "doctrine of signatures," where the plant's liver-shaped leaves were thought to indicate usefulness for liver and skin ailments. There is some documentation in historical herbals and ethnobotanical records that preparations of liverleaf were included in poultices or washes for minor wounds, which could include blisters. However, there is no robust evidence from controlled studies, nor is there a widespread modern herbal tradition that supports its topical use specifically for blisters. No relevant active compounds have been conclusively identified or studied for this effect. Thus, the use of American Liverleaf for blisters is grounded in historical/traditional practice rather than scientific validation, and the supporting evidence is weak and anecdotal, meriting a low evidence rating.