Buckhorn Plantain (Plantago lanceolata) has a long history of use in traditional herbal medicine, especially in Europe and North America. Folk remedies often recommend using the fresh leaves of Buckhorn Plantain as a poultice for skin injuries, including blisters, wounds, and insect bites. The leaves are typically crushed or chewed and then applied directly to the affected area. Traditional herbalists believe that Buckhorn Plantain possesses anti-inflammatory, soothing, and astringent properties, which may help alleviate discomfort and promote healing of minor skin irritations such as blisters.

While there is limited direct scientific evidence specifically validating Buckhorn Plantain for the treatment of blisters, some laboratory studies have demonstrated that extracts of Plantago lanceolata exhibit anti-inflammatory, antimicrobial, and wound-healing properties. These effects are attributed to the presence of bioactive compounds like aucubin, flavonoids, and tannins. However, the available research does not specifically address its efficacy for blisters, and most evidence remains anecdotal or based on traditional usage. As such, the use of Buckhorn Plantain for blisters is primarily justified by tradition rather than robust scientific validation.