Evidence supporting the use of: Epidermal Growth Factor
For the health condition: Blisters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Epidermal Growth Factor (EGF) is a protein that plays a key role in the regulation of cell growth, proliferation, and differentiation, particularly in epithelial tissues. Its application in the context of wound healing, including blisters, is supported by scientific research, although the majority of evidence comes from studies on chronic wounds, burns, and ulcers rather than simple, uncomplicated blisters. EGF promotes the migration and proliferation of keratinocytes and fibroblasts, which are essential for re-epithelialization and tissue repair. Several randomized controlled trials and meta-analyses have demonstrated the efficacy of topical EGF in accelerating healing in various types of wounds, especially in diabetic foot ulcers and burns. In the case of blisters, which are typically superficial wounds caused by friction, burns, or other trauma, the theoretical rationale for using EGF is based on its general wound healing properties. Some clinical and preclinical studies suggest that EGF can enhance the healing of partial-thickness skin injuries, which share some characteristics with blisters. However, direct high-quality studies specifically examining EGF for blister healing are limited. Nevertheless, the consistent benefit of EGF in wound healing more broadly provides moderate scientific justification for its use in more severe or persistent blister cases. EGF is not commonly used for minor blisters in standard practice, but may be considered in complicated or slow-healing cases.

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