Evidence supporting the use of: Great Plantain
For the health condition: Blisters

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Great Plantain (Plantago major) has a long history of traditional use for the treatment of minor skin injuries, including blisters. Historical texts and ethnobotanical records from Europe, Asia, and North America document the topical application of crushed plantain leaves to soothe wounds, reduce inflammation, and promote healing. The mucilaginous nature of the leaves is thought to create a protective barrier over the skin, while purported antimicrobial and anti-inflammatory properties help prevent infection and reduce discomfort.

However, while laboratory studies have shown that Great Plantain contains compounds with anti-inflammatory and antimicrobial activity (such as aucubin and allantoin), there is a lack of direct clinical research specifically evaluating its efficacy for treating blisters in humans. Most evidence remains anecdotal or based on historical use rather than controlled trials. Thus, its use for blisters is justified primarily by tradition, with some preliminary phytochemical support but no robust human data.

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