Evidence supporting the use of: Growth factors
For the health condition: Blisters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and fibroblast growth factor (FGF) have been scientifically investigated for their role in wound healing, including the treatment of skin injuries like blisters. Blisters, which are fluid-filled lesions typically resulting from friction, burns, or underlying disease, benefit from a rapid re-epithelialization process to restore the skin barrier and minimize infection risk. Growth factors are signaling molecules that regulate cell proliferation, differentiation, and migration—all critical steps in wound healing.

There is moderate clinical evidence supporting the use of topical growth factors in the management of chronic wounds, burns, and ulcers, but direct high-quality research specifically on blister healing is limited. However, the underlying mechanisms—enhanced keratinocyte migration, increased fibroblast activity, and accelerated tissue repair—are applicable to blistered skin. Several studies have shown that topical application of growth factor-containing preparations can speed up healing and improve outcomes in wounds similar to blisters, such as partial-thickness burns and skin graft donor sites.

Despite promising results, the routine use of growth factors for simple blisters is not widespread due to cost, limited direct evidence, and rapid natural healing of minor blisters. Their use is more justified for complicated or slow-healing wounds. Overall, growth factors have a scientific basis for their role in supporting skin repair, but specific evidence for treating uncomplicated blisters is moderate at best.

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Products containing Growth factors

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