The use of moisture to support or treat blisters is scientifically validated. Maintaining a moist environment for blister care is widely recommended in modern medical practice. The scientific basis is rooted in wound healing research, which consistently shows that moist wound environments promote faster healing and reduce the risk of infection compared to dry conditions. When a blister forms, the intact skin over the blister (the "roof") acts as a natural barrier, protecting the underlying tissue and keeping it moist. If a blister breaks or is intentionally drained, covering it with a sterile, non-adhesive, moisture-retentive dressing (such as hydrocolloid or silicone gel) helps maintain optimal moisture levels.

Moist wound healing supports cellular migration and proliferation, reduces dehydration and cell death, and can minimize pain and scarring. Multiple clinical guidelines, including those from dermatology and wound care associations, explicitly advocate for moist wound care as the standard approach for blisters, burns, and abrasions. Systematic reviews and randomized controlled trials have demonstrated that moist dressings not only accelerate re-epithelialization but also decrease infection rates compared to traditional dry dressings or exposure. Thus, the recommendation to keep blisters moist is solidly grounded in scientific evidence, with high-quality data supporting both efficacy and safety.