Sapindus mukorossi, commonly known as soapnut, has a long history of use in traditional medicine systems, particularly in Ayurveda and folk medicine of South Asia. Its fruit and pericarp are primarily valued for their saponins, which have natural cleansing and antimicrobial properties. In traditional contexts, decoctions or pastes made from Sapindus mukorossi have been used topically to support a variety of skin conditions, including blisters, wounds, eczema, and infections. The rationale for its use in blisters is generally attributed to its purported ability to cleanse the skin, reduce microbial load, and support healing by preventing secondary infection. However, there is little to no direct scientific research specifically validating its efficacy for treating blisters. Most published studies focus on its general antimicrobial, anti-inflammatory, and wound-healing properties in vitro or in animal models, not on human skin blisters specifically. Therefore, the evidence supporting its use for blisters remains primarily traditional, with anecdotal and historical records but lacking robust clinical trials or scientific validation.