Shen-chu (also known as "shenqu" or "medicated leaven") is a traditional Chinese medicinal ingredient commonly used in herbal prescriptions to aid digestion and improve appetite. Its traditional indications are not directly related to the treatment of blisters. However, in the context of traditional Chinese medicine (TCM), shen-chu may sometimes be included in complex herbal formulas for skin conditions, though this is not its primary function.

Historically, shen-chu is composed of fermented flour, herbs, and sometimes other ingredients, and is mainly valued for its ability to help with food stagnation and digestive complaints. The rationale for its inclusion in formulas addressing skin conditions such as blisters is based on the TCM theory that poor digestion and accumulation of "dampness" can manifest as skin eruptions or sores. Thus, shen-chu may be used to "resolve dampness" and promote the body's ability to heal, but not as a direct topical or specific remedy for blisters.

There is limited direct scientific evidence supporting the use of shen-chu for blisters. Its usage in this context is primarily rooted in traditional theory rather than empirical research. Therefore, the evidence rating is low, reflecting the lack of targeted studies for this specific condition.