Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Black cumin (Nigella sativa) has been traditionally used for a range of ailments, but its use for blood clot prevention has garnered some scientific interest in recent years. Several preclinical studies have indicated that thymoquinone, the main active compound in black cumin seed, exhibits antithrombotic effects. Laboratory and animal experiments suggest that Nigella sativa extracts can inhibit platelet aggregation and reduce factors associated with blood clot formation, such as thromboxane B2. For example, a 2013 study published in the journal Phytotherapy Research found that black cumin oil reduced platelet aggregation in rabbits. Another study in Blood Coagulation & Fibrinolysis (2016) reported decreased thrombus formation in rats treated with Nigella sativa extract.

However, clinical evidence in humans is sparse. While some small-scale human studies and anecdotal reports suggest possible benefits, no large, high-quality clinical trials have confirmed black cumin’s effectiveness in preventing blood clots or treating thrombotic disorders. Most available evidence remains limited to animal models and in vitro studies, with uncertain translation to clinical practice. Therefore, while there is scientific rationale and promising preclinical data, the overall evidence supporting black cumin for blood clot prevention in humans is still preliminary, warranting a moderate-low evidence rating (2/5).

Anyone considering black cumin for this purpose should consult a healthcare provider, especially since blood clot disorders are serious and require professional management.

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Designs For Health Annatto-E® Synergy (formerly Annatto Tocotrienols)