Evidence supporting the use of: Hesperidin
For the health condition: Blood Clots (prevention of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperidin is a bioflavonoid commonly found in citrus fruits and is often included in supplements aimed at supporting vascular health. Its use for the prevention of blood clots is primarily based on scientific rather than traditional evidence, though the strength of this evidence is moderate and not definitive. Several laboratory and animal studies suggest that hesperidin possesses anti-inflammatory and vasoprotective properties, which may help maintain healthy blood flow and reduce vascular inflammation, factors involved in blood clot formation. Some clinical trials, particularly those focused on chronic venous insufficiency and varicose veins, have shown that hesperidin (often combined with diosmin) can improve symptoms related to poor venous circulation, such as leg swelling and discomfort.

However, direct evidence supporting hesperidin’s efficacy in preventing blood clots (thrombosis) in humans is limited. The mechanism by which hesperidin may contribute to clot prevention is thought to involve the reduction of platelet aggregation and improvement of endothelial function, as suggested by in vitro studies and animal models. Nonetheless, there is currently insufficient high-quality human data to recommend hesperidin as a standalone therapy for blood clot prevention, and it should not replace established antithrombotic medications. In summary, while preliminary research supports a potential role for hesperidin in promoting vascular health, more robust clinical trials are needed to clarify its effectiveness specifically for blood clot prevention.

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