Evidence supporting the use of: Ligusticum
For the health condition: Blood Clots (prevention of)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ligusticum species, particularly Ligusticum chuanxiong (commonly known as Chuanxiong or Szechuan lovage), have been used in Traditional Chinese Medicine (TCM) for centuries to "invigorate blood" and "dispel blood stasis." These concepts are loosely associated with improving circulation and preventing blood clots in TCM theory. Chuanxiong is a key ingredient in many classical herbal formulas intended for cardiovascular health, stroke prevention, and conditions characterized by stagnation of blood flow.

Modern pharmacological studies have identified several active constituents in Ligusticum, such as ligustilide and ferulic acid, which exhibit vasodilatory, antiplatelet, and anticoagulant properties in laboratory settings. Some in vitro and animal studies suggest that extracts of Ligusticum can inhibit platelet aggregation and reduce blood viscosity, which could theoretically help prevent clot formation. However, robust clinical evidence in humans is limited, and most of the available support comes from tradition and preliminary pharmacological research rather than large-scale clinical trials.

In summary, Ligusticum is traditionally used to support blood circulation and prevent blood stasis, which TCM practitioners may interpret as prevention of blood clots. There is some scientific rationale from preclinical studies, but the evidence is not strong or definitive, and rigorous human trials are lacking. Thus, its use for blood clot prevention is primarily justified by tradition, with a modest scientific basis.

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