Evidence supporting the use of: Nattokinase
For the health condition: Blood Clots (prevention of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nattokinase is an enzyme extracted from natto, a traditional Japanese fermented soybean food. Its use for supporting blood clot prevention is based primarily on scientific evidence, though the quality and quantity of this evidence remain limited. Experimental studies (in vitro and in animals) have demonstrated that nattokinase exhibits fibrinolytic activity, meaning it can break down fibrin, a key protein involved in blood clot formation. Several small clinical trials in humans suggest that nattokinase supplementation may reduce plasma levels of fibrinogen, lower blood pressure, and enhance fibrinolytic activity. For example, a randomized, placebo-controlled trial published in 2008 found that nattokinase supplementation led to lower fibrinogen and factor VII levels in healthy adults, implying a potential antithrombotic effect. However, larger and more robust clinical trials are lacking, and there is insufficient evidence to recommend nattokinase as a primary therapy for blood clot prevention, especially in high-risk populations. Most guidelines do not recognize nattokinase as a substitute for conventional anticoagulant medications.

While the enzyme’s mechanism is scientifically plausible and early data are promising, the current evidence base is not strong enough for widespread clinical endorsement. The use of nattokinase should be approached with caution, particularly in individuals already on anticoagulant therapy, due to potential bleeding risk and lack of regulatory oversight for supplements.

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