Evidence supporting the use of: Sea vegetation (unspecified)
For the health condition: Blood Clots (prevention of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sea vegetation, such as various species of seaweed (e.g., kelp, wakame, kombu), has been investigated for its potential role in blood clot prevention, primarily due to its content of bioactive compounds like sulfated polysaccharides (e.g., fucoidan, carrageenan, and alginate). Several in vitro and animal studies have demonstrated that these sulfated polysaccharides possess anticoagulant and antithrombotic properties, which can inhibit blood clot formation. The mechanisms are thought to be similar to those of heparin, a clinical anticoagulant, involving potentiation of antithrombin III and inhibition of thrombin and factor Xa.

For example, research published in journals such as Thrombosis Research and Marine Drugs has shown that fucoidan extracted from brown seaweed exhibits significant anticoagulant effects. Limited small-scale human studies and pilot clinical trials have suggested possible benefits, but robust clinical evidence in large populations is lacking. While the preclinical data are promising, comprehensive clinical trials are required to confirm efficacy and safety for this indication in humans.

In summary, the use of sea vegetation for blood clot prevention has some scientific basis, primarily from laboratory and animal studies, but human evidence remains preliminary. Therefore, the evidence rating is moderate (3/5) and use should be considered experimental until further validated.

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