Evidence supporting the use of: Vitamin K mixed)
For the health condition: Blood Clots (prevention of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin K is scientifically validated as an essential factor in the coagulation (clotting) cascade, and its use in supporting or treating blood clotting disorders is well established. Vitamin K acts as a cofactor for the gamma-carboxylation of certain glutamate residues in proteins required for blood coagulation, including prothrombin and factors VII, IX, and X. Deficiency of vitamin K can result in impaired synthesis of these clotting factors, leading to increased bleeding risk and hemorrhagic disease. Supplementation with vitamin K—either as vitamin K1 (phylloquinone) or K2 (menaquinone)—is routinely used in clinical practice to prevent and treat bleeding disorders caused by deficiency, such as in newborns (to prevent hemorrhagic disease of the newborn), patients with malabsorption syndromes, or those on long-term antibiotics that disrupt gut flora. Conversely, vitamin K antagonists (like warfarin) are used as anticoagulants specifically because they inhibit the recycling of vitamin K and thus reduce clotting factor synthesis. While vitamin K supports normal clot formation and prevents excessive bleeding, it is not used to “prevent” blood clots in the sense of acting as an anticoagulant; rather, it prevents bleeding due to deficiency. The scientific evidence for its necessity and effectiveness in maintaining adequate blood clotting is robust, widely accepted, and forms the basis for its clinical use.

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