Evidence supporting the use of: Immunoglobulin
For the health condition: Blood Poisoning

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Immunoglobulin, specifically intravenous immunoglobulin (IVIG), has been investigated as an adjunctive therapy in the treatment of severe sepsis and septic shock, commonly referred to as "blood poisoning." The rationale for its use is based on its ability to modulate the immune response, neutralize bacterial toxins, and enhance opsonization and clearance of pathogens. Several randomized controlled trials and meta-analyses have assessed the efficacy of IVIG in this context. A 2013 Cochrane review suggested a potential mortality benefit with polyclonal IVIG, but highlighted significant heterogeneity and risk of bias among studies. More recent guidelines, such as the Surviving Sepsis Campaign, do not recommend routine use of IVIG in sepsis due to insufficient high-quality evidence for clear benefit and concerns regarding cost and availability. However, in certain clinical scenarios, such as cases of streptococcal toxic shock syndrome or when there is evidence of specific immunoglobulin deficiencies, IVIG may be considered. Overall, while there is some scientific basis and moderate evidence supporting immunoglobulin use in blood poisoning, especially in select populations or as adjunctive therapy, its routine use is not broadly recommended due to inconsistent evidence and ongoing debate in the scientific community.

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