Evidence supporting the use of: Immunoglobulin G
For the health condition: Blood Poisoning

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Immunoglobulin G (IgG), particularly in the form of intravenous immunoglobulin (IVIG), has been explored as an adjunctive therapy for blood poisoning, more accurately termed "sepsis." The rationale behind its use is that IVIG can provide passive immunity by supplying antibodies that may help neutralize pathogens, their toxins, and modulate the immune response, potentially reducing excessive inflammation observed in sepsis. Several clinical trials and meta-analyses have investigated the efficacy of IVIG in sepsis. Some studies suggest that polyclonal IVIG preparations may reduce mortality, especially in specific subgroups (such as neonates or those with severe bacterial infections). However, the overall evidence is mixed, with other trials failing to show a significant benefit in adult populations. Major guidelines, such as those from the Surviving Sepsis Campaign, currently do not recommend the routine use of IVIG due to insufficient high-quality evidence and concerns about study heterogeneity and bias. Thus, while the use of IgG for sepsis has a scientific rationale and some supportive data, it is not considered standard treatment, and its use is generally reserved for specific cases or within clinical trials. The evidence base is moderate but not definitive, justifying a rating of 3/5.

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