Prickly Chaff Flower (Achyranthes aspera) has a long history of use in traditional medicine systems such as Ayurveda and folk medicine in India and other Asian countries. In these traditions, it has been used for a variety of ailments, including as a supportive treatment for "blood poisoning," a term that often refers to sepsis or systemic infections. The rationale for its use is based on its purported anti-inflammatory, detoxifying, and antimicrobial properties as described in classical texts and ethnobotanical surveys.

However, scientific evidence supporting the use of Prickly Chaff Flower specifically for treating blood poisoning or sepsis is minimal. Some laboratory studies have shown that extracts of Achyranthes aspera possess antimicrobial and anti-inflammatory activities, but these findings are preliminary and mostly in vitro or in animal models. There are no high-quality clinical trials or robust scientific reviews confirming its effectiveness for blood poisoning in humans. The traditional use, therefore, is not well substantiated by modern research, and its efficacy and safety for this serious condition remain unproven.

In summary, while Prickly Chaff Flower is traditionally used as a remedy for blood-related disorders including so-called "blood poisoning," the scientific evidence to support its use for this specific condition is weak, justifying a low evidence rating.