Senna occidentalis (also known as coffee senna or septicweed) has a long-standing history in various traditional medicine systems, especially in tropical and subtropical regions, for treating a range of ailments, including what is referred to as "blood poisoning." In traditional contexts, "blood poisoning" often alludes to systemic infections, sepsis, or general toxic conditions of the blood. Healers in regions of Africa, Asia, and Latin America have used decoctions or infusions of Senna occidentalis leaves, roots, or seeds to "purify the blood" or address symptoms consistent with infection or toxicity.

However, there is minimal scientific evidence to validate the effectiveness of Senna occidentalis for the treatment of sepsis or systemic infections. Some studies have documented the antibacterial or antimicrobial activity of extracts from the plant in vitro, but these findings do not directly support its efficacy in treating blood poisoning in humans. Moreover, the plant is known to contain anthraquinones and other compounds that can be toxic at certain doses, raising safety concerns. There are no clinical trials or robust pharmacological studies to support its use for this indication.

In summary, the use of Senna occidentalis for "blood poisoning" is rooted in traditional medicine practices, but lacks substantial scientific validation or clinical evidence.