Evidence supporting the use of: Alpha-Ketoglutarate
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Alpha-Ketoglutarate (AKG) is sometimes marketed to bodybuilders and athletes based on its role in the Krebs cycle (a central metabolic pathway) and amino acid metabolism. The theoretical basis for using AKG in bodybuilding is that it could help enhance energy production, support protein synthesis, and aid in recovery. Some supplement companies also claim it may help reduce muscle breakdown and promote muscle growth.

However, scientific evidence supporting these claims is extremely limited. A handful of small human studies have explored AKG supplementation, mainly in clinical populations (such as critically ill patients or those undergoing surgery) rather than healthy athletes. There is little data specifically examining its effect on muscle mass, strength, or performance in bodybuilders. A few early studies suggested possible benefits for nitrogen balance and muscle protein metabolism, but subsequent research has not convincingly replicated these effects in athletes or healthy individuals.

Overall, the use of AKG for bodybuilding is based more on a plausible biochemical rationale than robust clinical evidence. Current research does not support significant benefits for muscle growth, recovery, or performance in healthy adults. While AKG is not without biological activity, its effectiveness as a bodybuilding supplement remains unproven.

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