Evidence supporting the use of: Citrulline aspartate
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citrulline aspartate is used in bodybuilding primarily for its potential to enhance exercise performance and reduce muscle fatigue. Scientific studies have evaluated its effects, with evidence suggesting that citrulline (often as citrulline malate, but sometimes as citrulline aspartate) can increase blood flow by boosting nitric oxide (NO) production, leading to improved oxygen and nutrient delivery to muscles during exercise. Several randomized controlled trials have reported that citrulline supplementation may delay the onset of muscle fatigue, increase the number of repetitions performed in resistance training, and reduce post-exercise muscle soreness. The aspartate component may also support energy production by participating in the urea cycle and reducing ammonia accumulation, potentially aiding endurance.

However, the majority of research specifically involves citrulline malate, and direct studies on citrulline aspartate are limited. The effects observed with citrulline aspartate are generally extrapolated from the broader citrulline literature. Some early studies from the 1980s and 1990s investigated citrulline aspartate in the context of reducing fatigue in athletes, but data remain sparse and sometimes conflicting. Overall, the scientific evidence supporting citrulline-containing supplements for bodybuilding and exercise performance is moderate (hence a score of 3), with more robust evidence for citrulline malate than for citrulline aspartate specifically. Therefore, while there is a scientific basis for its use, more research is needed to confirm the specific benefits of citrulline aspartate in bodybuilding.

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