Evidence supporting the use of: D-Aspartic Acid
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-Aspartic Acid (DAA) is an amino acid that has been investigated for its potential role in supporting bodybuilding, primarily due to its proposed effects on testosterone production. The rationale behind its use is based on early studies suggesting that DAA supplementation can increase endogenous testosterone levels, which could theoretically support muscle growth and strength gains.

Initial research, such as a 2009 study in healthy men, found that DAA supplementation increased testosterone by about 42% after 12 days. However, subsequent, more rigorous studies have cast doubt on these findings. For example, a 2013 study in trained men found no effect of DAA supplementation on testosterone or strength after 28 days. Several other studies in resistance-trained men have also reported no significant changes in testosterone, muscle mass, or performance outcomes with DAA supplementation.

Systematic reviews and meta-analyses suggest that while DAA may transiently increase testosterone in untrained or infertile men, these effects are not seen in healthy, resistance-trained males—the primary population interested in bodybuilding. No evidence supports significant improvements in muscle mass or strength attributable to DAA. Thus, while there is a scientific rationale and some initial evidence, the overall scientific consensus does not robustly support DAA’s efficacy for bodybuilding purposes, and the evidence is rated as weak (2/5).

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