Ethyl-Alpha-Guanido-Methyl-Ethanoate is better known as creatine ethyl ester, a modified form of creatine. Creatine, particularly in the form of creatine monohydrate, is among the most extensively researched and validated ergogenic supplements for body building and athletic performance. Numerous peer-reviewed studies have consistently shown that creatine supplementation increases muscle phosphocreatine stores, enhances high-intensity exercise performance, and supports muscle hypertrophy when combined with resistance training.

Creatine ethyl ester was developed with the aim of improving absorption over creatine monohydrate, though clinical evidence suggests its efficacy is not superior and may even be less effective due to rapid conversion to creatinine in the stomach. However, the core compound—creatine—remains scientifically validated for increasing muscle mass, strength, and exercise capacity, especially in short-duration, high-intensity activities.

The overall scientific consensus is that creatine supplementation, regardless of the specific esterified form, supports body building goals. The evidence rating of 4 reflects the robust support for creatine use in general, but acknowledges that the specific ethyl ester form is not superior to monohydrate and may not offer additional benefits.