Evidence supporting the use of: Methylepitiostanol
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylepitiostanol (also known as Epistane) is a synthetic anabolic-androgenic steroid (AAS) originally developed for potential medical use but has been primarily marketed and used as a performance-enhancing drug in bodybuilding communities. Its structure is derived from dihydrotestosterone (DHT), and it is known to exhibit anabolic effects such as increased muscle mass and strength while having relatively low androgenic and estrogenic activity compared to other anabolic steroids.

There is some scientific rationale for its use in bodybuilding: AAS like Methylepitiostanol promote protein synthesis and nitrogen retention in muscle tissue, which can contribute to hypertrophy and improved physical performance. Limited published studies (mostly preclinical and some human data on structurally similar compounds) support these mechanisms. However, direct high-quality clinical trials of Methylepitiostanol in athletes are lacking.

Despite its popularity, the evidence for its efficacy and safety profile in bodybuilding is weak, mostly limited to anecdotal reports and extrapolations from related anabolic steroids. It also carries significant risks, including hepatotoxicity, endocrine disruption, and potential legal issues, as it is classified as a controlled substance in many countries. In summary, while there is a scientific basis for its anabolic effects, robust clinical evidence is lacking, and its use is associated with considerable health risks.

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