Evidence supporting the use of: Phosphatidic Acid
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidic acid (PA) is a phospholipid molecule that has recently garnered interest as a nutritional supplement in the context of bodybuilding and muscle growth. The rationale for its use is based on its role in stimulating the mammalian target of rapamycin (mTOR) signaling pathway, which is central to muscle protein synthesis. Several small human studies have examined the effects of oral PA supplementation in combination with resistance training. For example, a 2013 double-blind, placebo-controlled study (Joy et al., Nutrition & Metabolism, 2014) found that subjects supplementing with 750 mg of PA daily experienced greater increases in lean body mass and strength compared to placebo over eight weeks of resistance training. Similar findings were reported in other small-scale studies, but results have been variable and often limited by small sample sizes, short durations, and funding from supplement manufacturers. While these preliminary studies suggest a potential benefit, systematic reviews and meta-analyses highlight that the current body of evidence is not robust, and the magnitude of the effect—if present—appears modest. There is a need for larger, independent, and longer-term studies to draw firm conclusions. Thus, while there is scientific rationale and some early clinical support for PA’s use in bodybuilding, the evidence base is limited and cannot yet be considered strong or definitive.

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Other health conditions supported by Phosphatidic Acid

Athletic and Exercise Aids
Body Building
Exercise
Muscle Tone (lack of)

Products containing Phosphatidic Acid

We currently have no products on Vitabase that contain this ingredient.