Evidence supporting the use of: Potassium alpha-ketoisocaproate
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Potassium alpha-ketoisocaproate (KIC) is a keto acid related to the amino acid leucine. It has been studied as a supplement for athletes and bodybuilders, primarily for its potential to reduce muscle breakdown and support muscle building. The rationale is that KIC may act as an anti-catabolic agent by serving as a nitrogen donor and modulating ammonia levels during intense exercise, possibly reducing fatigue and muscle breakdown.

Some small studies and preliminary research suggest that KIC, especially when combined with other compounds like HMB (beta-hydroxy beta-methylbutyrate), may help decrease muscle protein breakdown and promote muscle mass gains during resistance training. However, the evidence supporting the use of KIC alone for bodybuilding purposes is limited and not robust. Most clinical trials have small sample sizes, short durations, or combine KIC with other supplements, making it difficult to isolate its specific effects.

Overall, while there is a scientific basis for the potential mechanisms of KIC, the direct evidence supporting its efficacy for muscle growth or bodybuilding is weak to moderate. More extensive, high-quality clinical studies are needed to draw firm conclusions about its benefits for bodybuilders.

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Other health conditions supported by Potassium alpha-ketoisocaproate

Body Building
Exercise

Products containing Potassium alpha-ketoisocaproate

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