Evidence supporting the use of: Ursolic Acid
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ursolic acid, a natural compound found in apple peels and several herbs, has gained attention in the bodybuilding community for its purported muscle-building and fat-reducing properties. The scientific interest stems primarily from preclinical studies, especially in rodents. Key animal studies have demonstrated that ursolic acid supplementation may increase skeletal muscle mass, reduce adiposity, and improve metabolic profiles by enhancing insulin sensitivity and increasing energy expenditure. The proposed mechanisms include activation of the IGF-1 (insulin-like growth factor) signaling pathway and inhibition of muscle atrophy-associated genes.

However, human research is limited. A few small-scale clinical trials have explored its effects, with mixed results. For instance, a 2018 randomized controlled trial found no significant improvement in muscle strength or mass in resistance-trained men who supplemented with ursolic acid for 8 weeks, compared to placebo. Another pilot study suggested potential improvements in fat loss and minor gains in lean mass, but the sample sizes were small, and methodologies varied.

Overall, while animal data is promising, the current body of human evidence is insufficient and inconsistent. Most scientific reviews conclude more well-designed, larger clinical trials are needed before definitive recommendations can be made for ursolic acid as a bodybuilding supplement. Thus, although its use is grounded in preliminary science, the supporting evidence for effectiveness in humans remains weak at present.

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Products containing Ursolic Acid

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