Chokecherry (Prunus virginiana) has a history of use in various Native American traditional medicine systems, primarily as a remedy for coughs, colds, and digestive issues. There are anecdotal reports and ethnobotanical records that describe its use as a poultice or topical application for skin conditions, including boils, though such uses are not as thoroughly documented as its internal uses. The bark and fruit contain certain astringent compounds, such as tannins, which may have been thought to help “draw out” infections or reduce inflammation when applied topically. However, there is very limited direct scientific investigation into the efficacy of chokecherry for treating boils specifically. Modern pharmacological studies have focused on other properties of chokecherry, such as its antioxidant activity, rather than its use for skin infections. Therefore, while there is some traditional precedent for using chokecherry in this way, especially in the context of indigenous North American herbalism, the evidence supporting its effectiveness for boils is weak, and there is no substantial clinical or experimental validation available.