Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine is widely recognized for its role in supporting brain function, with a growing body of scientific evidence validating its use. Creatine is naturally present in the brain, where it helps maintain energy homeostasis by replenishing adenosine triphosphate (ATP), the primary energy currency of cells. Supplementation has been shown to increase brain creatine content, which is particularly beneficial under conditions of increased cognitive demand or metabolic stress.

Multiple studies have demonstrated that creatine supplementation can improve aspects of cognitive performance such as working memory, intelligence, and executive function, especially in populations with suboptimal dietary intake (e.g., vegetarians) or under conditions of sleep deprivation and mental fatigue. For instance, a 2003 randomized controlled trial by Rae et al. in "Proceedings of the Royal Society B" found that creatine supplementation improved working memory and intelligence test scores in young adults. Other studies suggest that creatine may help mitigate neurological decline in conditions like traumatic brain injury, aging, or neurodegenerative diseases, although more research is needed in these areas.

Overall, the evidence supports creatine’s use as a supplement for brain health and cognitive performance, particularly in circumstances where energy demand is high or stores are depleted. While not a panacea, its safety profile and the consistency of findings across studies justify its scientific use for supporting the brain-body system.

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