Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Grapes, particularly their skins and seeds, are rich in polyphenolic compounds such as resveratrol and flavonoids, which have been investigated for their potential neuroprotective effects. Scientific studies suggest that these compounds have antioxidant and anti-inflammatory properties, which may help support brain health by reducing oxidative stress and inflammation—both of which are implicated in neurodegenerative diseases and cognitive decline. Several animal studies and a limited number of small human clinical trials have shown that grape-derived polyphenols can improve certain aspects of memory, cognitive performance, and mood, especially in older adults. For example, resveratrol supplementation has been observed to improve hippocampal function and enhance cerebral blood flow in some studies. However, the overall evidence is still emerging, and larger, well-controlled human trials are needed to confirm these effects and understand optimal dosing and long-term safety. Historically, grapes have been consumed as part of a healthy diet, but their use specifically for brain health is driven by more recent scientific findings rather than longstanding traditional practices. In summary, grapes and their extracts show promise in supporting brain health, with moderate scientific evidence supporting their use in this context.

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