Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine is an amino acid involved in various physiological processes, including those in the central nervous system. Scientific studies have investigated glycine’s role as an inhibitory neurotransmitter in the brain and its potential effects on sleep quality, cognitive function, and neuroprotection. Some small clinical trials suggest that glycine supplementation may improve subjective sleep quality and reduce sleep onset latency in healthy individuals, possibly by modulating NMDA receptor activity and lowering core body temperature. There is also preliminary evidence indicating glycine could have calming effects and improve memory in certain contexts. However, these studies are generally limited in size and scope, and meta-analyses or large-scale trials supporting a robust benefit for overall brain health or cognitive enhancement are lacking. Glycine is not widely recognized as a primary treatment for neurological or psychiatric disorders, though it is sometimes used as an adjunct in research settings. In summary, while there is a scientific basis for glycine’s effects on the brain, the clinical evidence supporting its routine use specifically for “brain body system” support is modest and not yet conclusive. More rigorous studies are needed to firmly establish its efficacy for cognitive or neurological support in the general population.

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