Magnesium is an essential mineral that plays a critical role in supporting the brain and the broader nervous system. Scientifically, magnesium acts as a cofactor for more than 300 enzyme systems that regulate diverse biochemical reactions, including those involved in neuronal function and neurotransmitter synthesis. Evidence from clinical and preclinical studies suggests that adequate magnesium intake is associated with improved cognitive function, reduced risk of neurodegenerative diseases, and enhanced mood regulation.

Magnesium modulates N-methyl-D-aspartate (NMDA) receptors, which are involved in synaptic plasticity and memory function. Studies have found that magnesium deficiency can lead to neurological symptoms such as irritability, confusion, and even seizures. Randomized controlled trials have shown that magnesium supplementation may help reduce symptoms of depression and anxiety, likely through its effects on the hypothalamic-pituitary-adrenal (HPA) axis and neurotransmitter balance. Additionally, observational studies indicate that higher magnesium intake is linked to a lower risk of cognitive decline and migraine headaches.

While more large-scale clinical trials are needed to fully establish its therapeutic role, the current body of scientific evidence supports the use of magnesium for maintaining brain health and function.