Relationship: Brain and niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Brain

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacin (vitamin B3) has scientific validation for its role in supporting the brain and nervous system, but the strength of evidence for its use beyond deficiency states is moderate. Niacin is essential for the synthesis of NAD and NADP, coenzymes critical for cellular energy production and DNA repair. Severe niacin deficiency leads to pellagra, a condition marked by dementia, dermatitis, and diarrhea, clearly demonstrating the vitamin’s necessity for normal brain function. Supplementation with niacin reverses neurological symptoms in pellagra, which is a well-established clinical finding.

However, while niacin is essential for normal brain health, evidence supporting its use to enhance cognitive function in individuals without deficiency is limited. Some observational studies suggest a potential link between adequate niacin intake and reduced risk of cognitive decline or Alzheimer’s disease, but randomized controlled trials are lacking or inconclusive. Niacin’s role in neuroprotection is an area of ongoing research, with some laboratory studies suggesting it may help protect neurons from damage.

In summary, there is robust scientific support for niacin’s necessity in preventing deficiency-related neurological disorders, but evidence for benefits in brain health beyond deficiency is modest. Niacin is not typically used as a cognitive enhancer in the absence of deficiency, and high doses can cause side effects. Thus, its primary justification for brain support is based on its essential physiological role rather than as a therapeutic agent for healthy individuals.

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Other body systems supported by niacin (vitamin B3)

Arteries
Blood
Brain
Circulatory System
Digestive System
Glandular System
Heart
Hepatic System
Immune System
Liver
Mitochondria
Mucus Membranes
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Products containing niacin (vitamin B3)

Other body systems supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Health Concerns

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Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Brain

Table of Contents

Synopsis

Other ingredients that support Brain

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)For the body system: Brain

Table of Contents

Synopsis

Other ingredients that support Brain

Other body systems supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Brain