Evidence supporting the use of: Polyunsaturated fat
For the body system: Brain
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Polyunsaturated fats (PUFAs), particularly omega-3 fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have substantial scientific evidence supporting their role in brain health. These fatty acids are crucial components of neuronal cell membranes and play a key role in maintaining membrane fluidity, which is important for neurotransmission and synaptic plasticity. Numerous observational studies and randomized controlled trials have found that higher dietary intake of omega-3 PUFAs is associated with improved cognitive function, reduced risk of cognitive decline, and may be beneficial in neurodevelopment and neuroprotection.
DHA, in particular, is highly concentrated in the brain and is essential for normal brain development in infants and maintenance of brain function in adults. Deficiency in omega-3 fatty acids has been linked to cognitive impairment, mood disorders, and neurodegenerative diseases. Clinical guidelines from organizations such as the American Heart Association and European Food Safety Authority recognize the importance of omega-3 PUFAs for brain health, especially during pregnancy and early childhood.
While not all studies show dramatic effects, the accumulation of evidence supports the view that polyunsaturated fats, especially omega-3s, are beneficial for the brain-body system. The evidence is strongest for omega-3s, whereas omega-6 PUFAs are less directly implicated in brain health. Overall, the use of polyunsaturated fat to support the brain is justified by substantial scientific validation.
Other ingredients that support Brain
1,3,7-Trimethylpurine-2,6-dione3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
7,14-Hydroxy-Docosapentaenoic Acid
7,8-Dihydroxyflavone
Acetyl L-carnitine
Acetyl-L-Tyrosine
Acetylcholine
Adenosine triphosphate (ATP)
Agarwood
Agmatine
Albizia
Algae
algal oil
Algal protein
Almond fruit
Alpha glyceryl
Alpha lactalbumin
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-pinene
amino acids
AMP-activated protein kinase (AMPK)
anamu
anchovies
Angelica
animal protein
aniracetam
anserine
anthocyanidins
anthocyanins
anthocyanosides
antler
apigenin
apocynin
apple
arachidonic acid
arginine creatine
Arginine silicate
ashitaba
ashwagandha
asiaticoside
astaxanthin
Asteraceae
astragaloside
avocado
baccosides
Bacopa
Bacopin
bacoside
baicalein
baicalin
Baikal Skullcap
banana
Basidiomycota
basil
BCAA
bee pollen
bee products
beef
Beef liver
belleric myrobalan
benfotiamine
bergamot
berry
beta caryophyllene
beta phenethylalamine
beta-hydroxybutyrate
betony
bilobalide
biopterin
bird\'s nest
black cumin
black currant
black galingale
black garlic
black ginger
black pepper
black seed
black tea
blackberry
blubber oil
Blue-Green Alage
blueberry
bone marrow
borage
borneol
Boswellic Acid
bovine liver
brahmi
branched-chain amino acids
Brazil nut
breadnut
broad bean
broccoli
Brussel sprouts
butylphthalide
bасора
C-phycocyanin
cactus
caffeine
calamari oil
calamus
Calanus finmarchicus
Calea zacatechichi
California chia
California poppy
Camellia sinensis
cannabichromene
cannabidiol
cannabigerol
Cannabis sativa oil
Canscora
Capitate Valerian
cardamom
carnosic acid
Carnosine
carnosol
caryophyllene
cassia bark
catalpol
catechins
catecholamine
caterpillar mushroom
catuaba
cauliflower
Celastrus
Centella asiatica
Centella triterpenes
centrophenoxine
chaga mushroom
chamomile
cherry
chia seed
chia seed
Chinese mountain ant
Chinese salvia root
chocolate
chokeberry
choline
chrysanthemum
Cinidium
Cinnamomum
cinnamon
cistanche
citicoline
Citrus
citrus sinensis (proprietary)
Clary sage
Clerodendrum trichotomum
clove
coca
cocarboxylase
cocoa
coconut
cod liver oil
Codonopsis
coenzyme Q10 (CoQ10)
coffee fruit
cola nut
colostrum
Convolvulus pluricaulis
Convolvulus prostratus
copper
Coptis chinensis
cordyceps
Corydalis
cowage seed
cowslip
creatine
creatine monohydrate
crocetin
crocin
cruciferous
Crypthecodinium
Curculigo orchioides
Curcuma
curcumin
Curcuminoid
currant
cyanidin
cyanobacteria
cytidine
cytisine
d-alpha tocopherol
D-phenylalanine
damiana
danshen
date
deanol
decursin
deer velvet
dehydroascorbic acid
Dendrobium
dextrose
DHA (docosahexaenoic acid)
DHEA (dehydroepiandrosterone)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dibenzo-alpha pyrones
dihydrolipoic acid
dihydromyricetin
dismutase
DMPX
docosahexaenoic Acid
dopamine
DPA (docosapentaenoic acid)
dragonhead
dwarf morning glory
egg
Egg protein
eicosapentaenoic acid
electrolytes blend (proprietary)
eleuthero
elk antler
emblicanin
enokitake
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
Erythrina
essential oil blend
Ethyl-Alpha-Guanido-Methyl-Ethanoate
fat liver oil
fatty acids
fava bean
ferritin
feverfew
fibroblast growth factor
Ficus religiosa
fisetin
fish
fish oil
fish protein
Flammulina velutipes
flavanols
flavans
flavin mononucleotide
flavoglycosides
flavones
flavonoids
flavonols
flavonones
fo-ti
folate
folic acid
folinic acid
frankincense
fruit
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
fucosterol
fungus
GABA (gamma aminobutyric acid)
galantamine
gamma linolenic acid (GLA)
gamma-glutamylcysteine
ganoderma
gardenia
garlic
garlic bulb
gastrodia
gastrodin
Gelsemium
ginger
ginkgetin
ginkgo biloba
ginkgo biloba
ginkgo flavone glycoside
ginkgoheteroside
ginkgolides
Ginkgoside
ginseng
Ginsenosides
Glabridin
Glucoraphanin
glucose
Glutamate
Glutamic acid
Glutathione
glycerophosphocholine (GPC)
Glycine
goji berry
gooseberry
gotu kola
grape
Greek mountain tea
green tea
greens blend (proprietary)
Griffonia simplicifolia
guanidinoacetic acid
guanidinopropionic acid (GPA )
guarana
Guaranine
guayusa
Gypenoside
Haematococcus pluvialis
hazelnut
heal-all
hemp
hemp oil
herbal blend (proprietary)
Hericenones
hericium mushroom
hesperetin
Homotaurine
honey
Honokiol
hops
huperzine A
hydroxytyrosol
hyperforin
Hypericin
Hypericum
icariin
Idebenone
Ilex
Indian coraltree
Indian frankincense
Indian nightshade
Indian pipe
Indian tinospora
inosine
inositol
iridoids
iron
isothiocyanates
jasmine
Jatamansi
jiaogulan
jujube
jujubosides
Kaempferol
kale
kanna
kava
kavalactones
ketone salts
knotweed
kola nut
krill oil
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnitine
L-carnosine
L-glycine
L-phenylalanine
L-serine
L-taurine
L-theanine
L-tryptophan
l-tyrosine
lactalbumin
lactium casein decapeptide
Lactucarium
Large-leaved linden
lavender
lecithin
Legume protein
lemon balm
Lentil
Ligustrazin
linalool
linden
lingzhi
linoleic acid (LA)
lion's mane
lipids
liquid liver fractions
long pepper
longan
Loranthus
lotus seed
lutein
luteolin
Lycium
maca
macamides
mace
Maclura tricuspidata
magnesium
magnolia
magnolol
mandrake
mangiferin
Marine fat
Marine lipid
Marine protein
Marjoram
Marking Nut Tree
Matcha
Mate
Meadow sage
Mealy Kudzu
medium chain triglycerides (MCT)
Melatonin
Mesembrine
Methoxylated flavones
Methylcobalamin
Methylliberine
Methylxanthine
Milk Protein
Millet
Mimosa
Mineral ascorbate
Monoterpenes
Monounsaturated fat
Morinda
Moringa
Mortierella alpina
Mugwort
Muira puama
Mulberry
Mulungu
Mung bean
Mushroom
Myricetin
N-acetyl leucine
N-acetyl-cysteine (NAC)
NADH
Nannochloropsis
Nardostachys
Naringenin
Neem tree
Nervonic acid
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nigella seed
Nobiletin
noni
Nori
Nutmeg
Nymphaea caerulea
Nymphaea nouchali
oat
oleic acid
Oleoylethanolamide
Oligomeric proanthocyanidins
olive
omega-3 fatty acids
omega-6 fatty acids
omega-9 fatty acids
Onosma bracteatum
oolong tea
oriental arborvitae
oxaloacetic acid
Oxindole alkaloids
paeoniflorin
Palmitoylethanolamide (PEA)
pantothenic acid (vitamin B5)
paraxanthine
passionflower
Passionfruit
peanut
Pecan
peony
Pepper
Peptides
Periwinkle
Petiveria
phenolic compounds
Phenylethylamine (PEA)
Phenylpropanoids
phlorotannins
Phosphatidic Acid
phosphatidylcholine
Phosphatidylethanolamine
phosphatidylserine
Phosphocreatine
phospholipids
Phycocyanin
phytocannabinoids
Phytoplankton
pine bark
Piper chaba
Piperine
Pistachio
Plankton
Pleurotus eryngii
Polydatin
Polygala
polygala root
Polygonatum
Polygonum
polymethoxylated flavones
polyphenols
polysaccharides
polyunsaturated fat
pomegranate
poppy
potassium
pregnenolone
procyanidin
prolyl endopeptidase (PEP)
Propionyl-L-Carnitine
protein
pu-er tea
Puerain
Puerarin
pumpkin
purslane
Pycnogenol
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quercetin
quinoa
Quinoa Protein
Rauvolfia
reishi mushroom
relora® (proprietary)
resveratrol
rhizome
Rhodiola
riboflavin (vitamin B2)
Ribose-l-cysteine
robusta coffee
Rosabin
Rosarin
rosavins
rose
rose oil
rosemary
Rosmanol
rosmarinic acid
Rosy conk
royal jelly
Rubiaceae
rue
Sacha Inchi
saffron
Safranal
sage
Salidroside
Salmon Oil
salt
Salvia
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
Sarcosine
sceletium
Schisandrins
Schizandrol A
Schizochytrium
Schizochytrium Oil
seaweed
selenium
Selenocysteine
Selenomethionine
Semecarpus anacardium
sesame
Sesamin
Sesquiterpenes
Shankhpushpi
Shilajit
Sialic acid
Sida cordifolia
silk tree
skullcap
Snakeroot
Southern Tsangshu
Soy
soybean
spearmint leaf
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
Sphingomyelin
Spikenard
spinach
spirulina
St. John's Wort
Stearidonic acid
Stephania root
Stilbenoid
strawberry
Sulbutiamine
Sulforaphane
sulforaphane glucosinolate
Sumbul
sweet flag
Szechuan lovage
Tagara
Tangeretin
Tanshinone
Taurine
Taxifolin
Tea
Teacrine
Terminalia
terpene lactones
Terpenoids
Tetrahydropalmatine
Theacrine
Thiamin (vitamin B1)
Threonic acid
thyme
Thymoquinone
Tinospora cordifolia
tocotrienols
Tongkat ali
trace minerals
Trans-pterostilbene
Tremella
Triacetyluridine
Trichilia catigua
Trichopus zeylanicus
Triphala
Troxerutin
Tumerone
turmeric
Turmerones
ubiquinol
Uncaria
Uridine
Urolithin A
Valerenic acid
Valerian root
vegetable and fruit blend (proprietary)
Vegetable Protein
velvet bean
Verbena
Vervain
Vetiver
Vinburnine
Vincamine
Vine tea
Vinpocetine
vitamin A
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
Vitexin
Walnut
Waterhyssop
wheat germ
Whey protein
White Tea
Willow
Withanolides
Wogonin
Wood betony
Xanthine
Xanthohumol
Xylaria nigripes
Yerba mate
Zapilopatle Bean
Zinc
Zinc
β-nicotinamide mononucleotide (NMN)
Other body systems supported by polyunsaturated fat
ArteriesBlood
Brain
Circulatory System
Eyes
Female Reproductive System
Heart
Immune System
Joints
Liver
Nerves
Prostaglandins
Reproductive System
Skin