Evidence supporting the use of: Diindolylmethane
For the health condition: Breast Lumps

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and Brussels sprouts. Its use in supporting or treating breast lumps, particularly those associated with fibrocystic breast changes or hormone-sensitive conditions, has some scientific basis but is not strongly established through large, high-quality clinical trials. The rationale for DIM's use stems from its ability to influence estrogen metabolism; it promotes the production of less potent estrogen metabolites, which may reduce estrogenic stimulation of breast tissue. This has led to hypotheses that DIM could be beneficial for hormone-related breast conditions, including benign breast lumps. A handful of small clinical studies and preclinical research support the notion that DIM may affect estrogen metabolism and modulate the risk of estrogen-sensitive conditions. However, direct evidence for DIM's efficacy in treating or reducing benign breast lumps is limited. Most available studies focus on breast cancer prevention, estrogen metabolism, or measurements of hormone levels, rather than direct effects on benign breast lumps. The evidence base is mostly preliminary, with some encouraging biochemical and mechanistic data, but lacks robust clinical outcomes specific to breast lumps. In summary, while there is a scientific rationale and some supporting data for DIM's use in hormone-related breast health, the evidence for its effectiveness in treating or supporting breast lumps is limited and rated as low to moderate.

More about Diindolylmethane
More about Breast Lumps

Products containing Diindolylmethane

We currently have no products on Vitabase that contain this ingredient.