Evidence supporting the use of: Agnuside
For the body system: Breasts

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Agnuside is an iridoid glycoside found primarily in the fruits of Vitex agnus-castus (chasteberry). Its use to support the breasts body system comes chiefly from traditional herbal medicine practices, especially in Europe and the Mediterranean. Historically, chasteberry preparations (which contain agnuside among other compounds) have been used to address premenstrual symptoms, breast tenderness (mastalgia), and cyclical breast discomfort associated with the menstrual cycle. The traditional rationale is that chasteberry modulates hormonal balance, particularly by affecting prolactin levels, and thereby may help alleviate symptoms like breast pain that are linked to hormonal fluctuations.

However, the scientific evidence directly linking agnuside itself (as opposed to whole chasteberry extracts) to breast health is limited. Most clinical research has evaluated the effects of chasteberry as a whole rather than isolated agnuside, and results have shown some benefit for cyclical mastalgia and PMS-related breast discomfort. The mechanism is thought to involve dopaminergic effects that reduce prolactin secretion. Despite the traditional use and some supporting clinical studies for chasteberry, there is insufficient specific evidence to credit agnuside alone with these effects. Thus, the use is justified by tradition, with moderate but not robust clinical evidence for the whole plant extract and only limited inference for agnuside itself.

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