Evidence supporting the use of: Bone morphogenetic protein
For the health condition: Broken Bones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Bone morphogenetic proteins (BMPs) are a group of growth factors that are well-established in the scientific literature for their role in bone formation and healing. Discovered in the 1960s, BMPs—particularly BMP-2 and BMP-7—have been shown to induce the differentiation of mesenchymal stem cells into bone-forming osteoblasts. This property has been leveraged clinically, and recombinant human BMPs (rhBMP-2 and rhBMP-7) have received FDA approval for specific orthopedic applications, such as spinal fusions and the treatment of certain types of complex fractures or non-unions where bone healing is problematic.

Multiple randomized controlled trials and meta-analyses have demonstrated that BMPs can enhance bone healing and fusion rates, particularly in cases where traditional bone grafts are not feasible or have failed. Their use is supported by a robust scientific and clinical evidence base, and professional guidelines have outlined specific indications for their use. However, BMP application is not without risks—adverse effects such as inflammatory reactions, ectopic bone formation, and increased cancer risk in some populations have been reported, leading to careful patient selection and monitoring.

In summary, the use of bone morphogenetic proteins for supporting and treating broken bones is strongly justified by scientific evidence, with high-level studies validating their efficacy in promoting bone regeneration in selected clinical situations.

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Other health conditions supported by Bone morphogenetic protein

Arthritis
Broken Bones
Cartilage Damage
Injuries
Surgery (healing from)

Products containing Bone morphogenetic protein

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