Evidence supporting the use of: Ma Huang
For the body system: Bronchials

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Ma Huang (Ephedra sinica) has a long history of use in traditional Chinese medicine for the treatment of respiratory conditions, particularly to support the bronchial system. The primary active compounds in Ma Huang are ephedrine and pseudoephedrine, which are well-known sympathomimetic agents. These alkaloids act as bronchodilators by stimulating adrenergic receptors in the respiratory tract, leading to relaxation of bronchial smooth muscle and improved airflow.

Multiple scientific studies have confirmed the bronchodilatory effects of ephedrine, and pharmaceutical preparations containing synthetic or natural ephedrine were historically common in the management of asthma and bronchitis before newer agents became available. Clinical trials in the mid-20th century demonstrated significant improvements in bronchial constriction and relief of asthma symptoms with ephedrine use. However, concerns about cardiovascular side effects, potential for misuse, and safety have led to restrictions on the use of Ma Huang and ephedrine-containing supplements in many countries.

Despite regulatory limitations, the pharmacological basis for Ma Huang's action on the bronchial system is well-established, and its traditional use is supported by modern scientific validation. It remains an important historical and pharmacological reference in the context of respiratory support, though it is no longer a first-line therapy due to safety considerations.

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