Devil's Club (Oplopanax horridus) has a long history of use among Indigenous peoples of the Pacific Northwest, who have utilized various parts of the plant for a range of ailments, including as a poultice for wounds, swellings, and bruises. Ethnobotanical records indicate that the inner bark was often mashed and applied directly to the skin to reduce pain and inflammation. The rationale for its use in bruises likely stems from its perceived anti-inflammatory and analgesic properties, as described in oral histories and ethnographic literature. However, while traditional use is well documented, there is minimal scientific evidence to validate its efficacy specifically for bruise prevention or treatment. Preliminary phytochemical analyses suggest Devil's Club contains compounds such as polyynes, glycosides, and saponins, some of which have shown anti-inflammatory activity in vitro. Despite this, no clinical studies or robust preclinical trials confirm its usefulness for treating or preventing bruises in humans. Thus, the support for Devil's Club in this context is rooted primarily in tradition rather than scientific validation, and the evidence base remains weak.