Evidence supporting the use of: Endopeptidase
For the health condition: Bruises (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Endopeptidases, such as bromelain and serrapeptase, are proteolytic enzymes that have been studied for their potential to reduce bruising and support healing after soft tissue injury or surgery. The rationale is that these enzymes help break down fibrin and other proteins involved in inflammation and hematoma formation, thereby accelerating the resolution of bruises. Several small clinical studies, particularly with bromelain, have shown modest reductions in swelling, pain, and bruising following surgery or trauma when compared to placebo. However, the overall quality of the evidence is limited: most studies are small, not always well-controlled, and often combine endopeptidases with other interventions.

Systematic reviews and meta-analyses generally conclude that there is some evidence for the benefit of oral proteolytic enzymes in reducing edema and bruising, but the strength of this evidence is low due to methodological limitations. While bromelain is the most studied, evidence for other endopeptidases like serrapeptase is even less robust. These enzymes are generally considered safe when used appropriately, but concerns about allergic reactions and gastrointestinal side effects exist.

In summary, while there is some scientific support for the use of endopeptidases to help reduce bruising, the evidence is not strong, and more rigorous clinical trials are needed to establish definitive efficacy. Their use is primarily based on preliminary scientific data rather than strong, consistent clinical validation.

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Products containing Endopeptidase

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