Evidence supporting the use of: Vitamin B1 (fursultiamine)
For the health condition: Burning Feet or Hands

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B1, also known as thiamine, and its derivative fursultiamine, have a scientific basis for their use in the treatment of burning feet or hands, particularly when these symptoms are due to peripheral neuropathy associated with thiamine deficiency (commonly known as beriberi). Historically, the "burning feet syndrome" was described in populations with a diet deficient in thiamine, and supplementation alleviated symptoms. Fursultiamine is a lipophilic thiamine derivative developed to improve the bioavailability of vitamin B1, allowing for better tissue penetration and efficacy in treating deficiency states, especially in neuropathic conditions. Several clinical studies and reviews have reported beneficial effects of thiamine and its derivatives for neuropathic symptoms, including burning, tingling, and numbness in the extremities. In Japan and some other countries, fursultiamine is used as a treatment for peripheral neuropathy, including diabetic and alcoholic neuropathy, conditions where "burning feet" is a common complaint. However, while the evidence is stronger for thiamine deficiency states, there is less robust support for efficacy in neuropathies not related to deficiency. Overall, the evidence justifying the use of fursultiamine for burning feet or hands is moderate (rating: 3/5), particularly when the underlying cause is thiamine deficiency or neuropathy responsive to vitamin B1 supplementation. The use is supported by mechanistic plausibility, historical clinical observations, and some controlled studies, but high-quality large-scale RCTs are limited.

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