Evidence supporting the use of: Vitamin B1 (Thiamine)
For the health condition: Burning Feet or Hands

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B1 (Thiamine) has a scientifically established role in preventing and treating certain neuropathies, including symptoms like burning feet and hands. The association was first recognized in the early 20th century when severe thiamine deficiency led to the disease beriberi, which commonly presents with peripheral neuropathy—characterized by pain, tingling, and burning sensations in the extremities. Numerous clinical and epidemiological studies have since confirmed that thiamine supplementation reverses these neuropathic symptoms in individuals with deficiency. However, for burning feet or hands not caused by thiamine deficiency, the evidence is less robust. Some small studies and case reports suggest thiamine may help in diabetic neuropathy and other neuropathic conditions, but systematic reviews and larger trials provide mixed results.

Overall, the use of thiamine for burning feet or hands is well-supported in the context of deficiency states, but the evidence for benefit in other causes of neuropathy is limited and inconsistent. As such, thiamine supplementation is primarily indicated in patients at risk for or with confirmed deficiency, such as those with alcoholism, malnutrition, or malabsorption syndromes. Routine use for idiopathic burning sensations without evidence of deficiency is not well supported by current scientific literature.

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