Evidence supporting the use of: Vitamin B1 (thiamine diphosphate)
For the health condition: Burning Feet or Hands

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B1 (thiamine diphosphate) is scientifically justified for use in supporting or treating burning feet or hands, particularly when the symptoms are due to thiamine deficiency (beriberi). Historically, thiamine deficiency was first recognized in the late 19th and early 20th centuries as the cause of beriberi, a disease characterized by peripheral neuropathy, which can manifest as burning sensations, tingling, numbness, and weakness, especially in the extremities.

There is strong evidence from both classical clinical observations and modern studies that thiamine supplementation rapidly improves neuropathic symptoms in patients with deficiency. Beriberi was common in populations consuming polished rice, leading to widespread burning feet and hands, which responded dramatically to thiamine administration. Clinical textbooks and reviews continue to recognize thiamine deficiency as a reversible cause of peripheral neuropathy, with burning feet or hands a classic presentation.

However, the evidence supporting thiamine supplementation in neuropathic symptoms not related to deficiency is less robust. Most clinical benefit has been demonstrated in deficiency states, and large, high-quality trials for idiopathic neuropathy are lacking. Nevertheless, thiamine is sometimes used empirically in neuropathy cases, especially if nutritional status is uncertain. Overall, the scientific evidence for thiamine's effectiveness in burning feet or hands is strong when related to deficiency, but limited for other causes.

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