Evidence supporting the use of: Amino Acid Chelate
For the health condition: Calcium Deficiency

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Amino acid chelates are mineral complexes in which minerals such as calcium are bound to amino acids, typically glycine. This chelation process is designed to improve the absorption and bioavailability of the mineral compared to traditional inorganic salts like calcium carbonate or calcium citrate. Scientific research supports the use of calcium amino acid chelates for addressing calcium deficiency, as several studies have demonstrated that these chelated forms are absorbed more efficiently in the intestines. For example, a review in the journal Biological Trace Element Research (2012) highlights improved absorption and retention of chelated minerals compared to their inorganic counterparts. The improved bioavailability is attributed to the stability of the chelate in the digestive tract and its ability to utilize amino acid transport pathways. However, while there is clear evidence that amino acid chelates can increase calcium absorption, there is less robust data directly linking them to superior clinical outcomes (such as increased bone mineral density or reduced fracture rates) compared to other well-absorbed forms of calcium. Therefore, the evidence is rated at 3: there is scientific validation for improved absorption and potential benefit, but not enough high-quality, long-term trials to confirm that chelated calcium is significantly more effective in preventing or treating calcium deficiency-related diseases in the general population.

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