Magnesium citrate malate is used to support or treat calcium deficiency primarily based on scientific rationale, though the evidence is of moderate strength. Magnesium is an essential mineral that plays a critical role in bone health and calcium metabolism. Several studies have demonstrated that magnesium is necessary for the proper function of parathyroid hormone and the activation of vitamin D, both of which are key regulators of calcium absorption and homeostasis. Magnesium deficiency can impair calcium balance and contribute to hypocalcemia (low calcium levels).

Magnesium citrate malate is a bioavailable form of magnesium, meaning it is well absorbed and utilized by the body. While direct evidence for magnesium citrate malate treating calcium deficiency specifically is limited, there is robust evidence that magnesium supplementation in general can help address calcium metabolism disturbances, particularly in individuals who are magnesium deficient. Some clinical studies show that correcting magnesium deficiency may improve calcium status, especially when calcium deficiency is secondary to low magnesium levels.

However, magnesium citrate malate is not a source of calcium itself, and it cannot directly replace calcium in cases of dietary or absolute calcium deficiency. Its use is best justified in scenarios where magnesium deficiency is contributing to calcium imbalance. Thus, scientific evidence supports its adjunctive role in managing calcium deficiency, but it is not a primary or standalone treatment for this condition.