Evidence supporting the use of: Potassium citrate malate
For the health condition: Calcium Deficiency
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Potassium citrate malate is supported by scientific evidence as a supplement to aid in calcium balance and bone health, though it is not a direct treatment for calcium deficiency. Studies have shown that potassium citrate and similar alkaline potassium salts can reduce urinary calcium excretion and decrease bone resorption, thereby supporting calcium conservation in the body. This effect is particularly relevant in conditions where high dietary acid load or certain metabolic disorders promote calcium loss from bones. Clinical trials have demonstrated that supplementation with potassium citrate or potassium citrate malate can reduce bone turnover markers and enhance the effect of calcium supplements on bone mineral density, especially in postmenopausal women and individuals at risk for osteoporosis.
However, potassium citrate malate does not contain calcium itself; rather, it acts by altering the body's acid-base balance, promoting calcium retention. The evidence for its use is strongest in contexts of bone health and prevention of osteoporosis rather than for treating overt calcium deficiency (hypocalcemia), which typically requires direct calcium supplementation. Systematic reviews and clinical guidelines recognize alkali therapy as an adjunct to calcium and vitamin D for bone health, not as a primary treatment for calcium deficiency. Thus, scientific evidence supports its use in supporting calcium balance and bone health, but not as a standalone therapy for true calcium deficiency.
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Other health conditions supported by Potassium citrate malate
Calcium DeficiencyCalcium Deposits
Gout
Hypertension
Kidney Stones
Osteoporosis
Uric Acid Retention